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KMID : 0670820100150040157
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Korean Journal of Medical Mycology
2010 Volume.15 No. 4 p.157 ~ p.164
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Antifungal Effects of the Extracts and Essential Oils from Foeniculum vulgare and Illicium verum against Candida albicans
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Park Sung-Ho
Seong In-Wha
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Abstract
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Background: Candida albicans is a member of the normal flora of the skin, mucous membrane and gastrointestinal tract. Vaginal candidiasis remains a significant problem in women in childbearing age, Majority of the cases are caused by C. albicans and recurrence is common in spite of topical treatment.
Objective: The purpose of this study is to develop the antifungal agent from the medicinal herbs traditionally used in Korea.
Method: In this study, the extracts and essential oils from Foeniculum vulgare and Illicium verum were examined for antifungal activities against C. albicans.
Result: Dichloromethane extracts and essential oils from Foeniculum vulgare and Illicium verum showed antifungal activity against C. albicans. One fraction from Illicium verum with antifungal activity was founf out as 1-methoxy-4-(2-prophenyl) benzene.
Conclusion: Dichloromethane extract and 1-methoxy-4-(2-prophenyl) benzene with antifungal activity from Illicium verum could be the candidate for a new antifungal agent for candidiasis and other fungal diseases. [
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KEYWORD
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Illicium verum, Extract, Antifungal activity, Candida albicans
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